Search the web of National Geographic Travelers. In 2000, there was a special issue of 50 places in the world, under different categories.
You didn't say what you like to do for your vacation, so can't tell you too much, except:
1. For romance, go to Venice, Italy with your girlfriend, not your wife.
2. For Muslim culture, go to Istanbul, Turkey.
3. For Catholic culture, go to Vatican, Italy.
4. For gambling, Las Vegas, or Macao. Bring plenty of cash.
5. For swimming with dophine and stingray, go to Cayman Island.
6. To eat, go to Italy or France. The best is Shanghai. Trust me.
7. To shop (luxury), Rome, Paris, New York and Hong Kong.
8. To shop (non luxury), any factory outlet mall in USA.
9. For one night stand, Highway 55 in Germany, or just go to ShenZhen.
The best I like in the world: hilly towns in Tuscany (Tocana in Italian) in Italy.
Fresh today for your consideration. Florence is in Tuscany.！